Paradigm is a leading crypto investor, with notable seed investments in Blur, Blast, and Friend.tech. They have a broad investment appetite, deploying capital across various sectors, from DeFi and NFTs to fundamental crypto infrastructure. Their role in elevating Flashbot to unicorn status further bolstered its reputation.

Binance Labs Fund capitalized on the extensive Binance network, leading investments in several projects like Pendle and Cyberconnect. Their access to companies across multiple blockchains sets them apart from competitors.

Coinbase Ventures stands out for making more deals than any other VC fund in 2023. They invested in startups such as Wormhole, Mauve, and Supra. Their investments covered an impressive array of verticals, including DeFi, gaming, infrastructure, marketplaces, and security.

Polychain Capital made its name by focusing on big bets within the decentralized world. They led the way with a $165 million investment in the series-B round for Uniswap, currently the world's largest decentralized exchange.

Shima Capital, based in Puerto Rico, invests primarily in early-stage ventures. Known for their pre-seed round investments in blockchain start-ups they have led the seed funding for Artela and Mythic Protocol, with an investment of over $6 million in each.